Endocrine Abstracts

Introduction: Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) have been conjectured to arise from well differentiated thyroid carcinoma (WDTC) due to frequently reported synchronous and metachronous occurrence. We demonstrate the simultaneous presence of divergent histological subtypes in a single thyroid gland, with escalating loss of p53 expression in more aggressive variants.Material and methods: A 60-year-old mal...

Introduction: Graves’ disease is a multi-system autoimmune disease characterized by hyperthyroidism, ophthalmopathy and pretibial myxedema. The disease presents with hyperthyroidism or more rarely with ophthalmopathy. It runs a various course and many times during its natural course permanent hypothyroidism may ensue.Aim: The aim was to describe the case of a patient with Graves’ disease presenting with ophthalmopathy and subclinical hypothyroi...

Introduction: Graves’ disease (GD) is an autoimmune thyroiditis frequently associated with development of Graves’ orbitopathy (GO). GD patients have lower vitamin D levels compared to the general population. Whether low vitamin D levels are associated with GO is still controversial. The aim of our study was to assess the vitamin D levels in patients with GO and the clinical outcome.Methods: This is a single-center observational study in an outp...

Introduction: Long term treatment with corticosteroids has been widely used, due to the well documented immunosuppressive and anti-inflammatory activity. Corticosteroids are among the most widely prescribed drugs in oncology and post-transplant patients. However, long-term treatment with a dose of corticosteroids, which equals prednisolone 5mg/day for at least 4 weeks, is very likely to result in suppressed function of the hypothalamic pituitary adrenal (HPA) axis, a condition...

Introduction: Regardless of the fact that the incidence of thyroid cancer has increased significantly in recent years, the simultaneous occurrence of multiple tumors in one thyroid gland is still a rare phenomenon. These tumors have the morphology, either of a single mass with mixed histological features, or of a single lesion consisting of two distinct cell-populations, or of two different tumors between which normal thyroid tissue is interposed. Various theories have been pr...

Introduction: Worldwide, diabetes is a common metabolic disorder that creates many complications. Nowadays a mobile-based application could be included in the therapeutic approaches of self-management.Aim: This study presents the development of a mobile application named ‘Diabetes 2 Learn’ for people with type 2 diabetes inside the Greek population.Methods: Google Play and App Store were examined for their apps on diabete...

Introduction: Pheochromocytoma (PHEO) is a rare neuroendocrine tumor, which presents with various clinical phenotypes, depending on the size of the tumor, the secreting activity, and the secreting product. Large PHEOS exhibit symptoms related to mass effects and malignant PHEOS symptoms related to metastases. Some PHEOS present as adrenal incidentalomas (AI) or with an unusual clinical phenotype.Case report: A 54-year-old Russian female presented with se...

Objective/Design: Gestational diabetes mellitus (GDM) has been associated with serious complications for both the pregnant woman and the newborn. Vitamin B12 is implicated in some important metabolic procedures such as methylation and one carbon cycle and its deficiency can cause serious health problems, such as hyperhomocysteinemia, defective synthesis of neurotransmitters and fatty acids and more. However, it is not known if there is a link between vitamin B12 deficiency and...

Adrenocortical tumorigenesis has been observed in mice. It is speculated to be gonadotropin dependent. In particular LH receptors appear to be found within such adrenal tumors in high density and elevated LH levels may be related to adrenal tumorigenesis. The aim was to describe the case of a patient who after ovariectomy developed a large malignant adrenal tumor. A patient, female, aged 42 presented with uterine leiomyomas. She was treated by surgical excision of the uterus a...

Osteoporosis is a bone disease predisposing to bone fragility. Nowadays, the population is screened for osteoporosis and measures are taken for fracture prevention. Additionally, people are urged to have a diet rich in calcium, are given calcium supplements and are being treated for vitamin D deficiency. Moreover, osteoporosis treatment is administered. Therefore, the relationship between osteoporosis and fractures in the real world setting is very interesting.<p class="ab...